You can see it had large windows and a striped awning. One of the most common changes to many old commercial buildings is their conversion to residential use. The large display windows are simply removed and space bricked up.
Take a look around some day for similar buildings. It's interesting to realize how many neighborhoods had little stores sprinkled through them. The same sort of centralized shopping districts that killed the shopping districts (ex., Stapleton, Port Richmond, etc.) probably put the end to them as well.